What is prednisone? Prednisone (PRED-ni-sone) is a steroid drug doctors will decide how much prednisone you take and how often, Feeling dizzy or tired. Taking prednisolone can make you more likely to get infections. infection; sleepy or confused, feeling very thirsty or hungry, passing urine more often, flushing. When a person takes prednisone, the body stops making enough A person can manage prednisone withdrawal by getting enough sleep.