Diphenhydramine and ibuprofen is a combination medicine used to treat Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other. These medicines may cause some risk when taken together. Taking ibuprofen 8 hours before or 30 minutes after the aspirin may help avoid the problem. Ibuprofen-diphenhydramine is a combination product containing a non-steroidal anti-inflammatory drug (NSAID) and an antihistamine. Ibuprofen, the NSAI.