Diabetes and SteroidsWhat patients should know: something commonly known as a “medrol dose pack” when they visit a urgent care or E.R. clinic. Apr 15, I've taken care of patients without diabetes that get blood sugar spikes from steroids. The Medrol dose pack is for 5 days or something like that. Medrol (Medralone) glucocorticosteroid anti-inflammatory side effects, how it's given, how If you have diabetes, Medrol may increase your blood sugar levels. If this process continues, it causes insulin resistance. Join the Diabetes Forum More info the Newsletter. September 9, Reply. How does diabetes affect the body? Ray White, Stormville, New York. Already submitted. All content is strictly informational and should not be considered medical advice. Notify me of followup comments via e-mail.