There are a few tried and true chest congestion remedies as well as some effective over the counter treatments. Here's how to clear chest congestion naturally. How to Clear Chest Congestion. Chest congestion is uncomfortable and unpleasant, but fortunately there are many ways you can loosen up. congestion. See how to help relieve chest congestion and get relief with Mucinex®. It's your body's natural fighting response to an irritant. Though it's one of.