Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Do not take this medicine in larger amounts or for longer than recommended. a diuretic or "water pill"; or; diphenhydramine (Benadryl) used on the skin. Benadryl can cause side effects, including sedation and drowsiness, which impair coordination and. Jun 6, Many of the prescription medications we take have interactions with other [ ] Aspirin, ibuprofen (Motrin), and Aleve (naproxen) can boost the effect of This class interacts with Benadryl (diphenhydramine), which is found in.
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