This fluid build-up can cause breathlessness and wheezing. a feeling of tightness in the chest;; difficulty in breathing or shortness of breath;; wheezing; and. Although physicians may be familiar with the chest pain described by some asthmatics during attacks the phenomenon has not been studied, nor does it merit a. If you have asthma, a respiratory condition that causes breathing difficulties, you might experience chest pain. This symptom is common right.